Bioreactor with Filter
CellBios® Bioreactor with filter is a single use reactor bag used for cell separation, processing and expansion during cell culture and drug discovery applications.
Ranging from 2 L to 50 L
CellBios® is one of the leading companies in the world to offer bioreactors with filter in 6 different configurations from 2 L to 50 L. It is made up of multi layered PE film and Nylon filter material with a pore size of about 1.2µm. The type of filter that is used in a bioreactor will depend on the specific application. For example, depth filters are often used for prefiltration, while membrane filters are often used for sterile filtration.
FEATURES
- Specially designed for easy fluid handling
- Excellent durability and toughness
- Highly sealable and weldable to provide leak resistance
- Exhibits superior clarity and transparency for good visibility
- Excellent gas barrier properties
- Reduces the risk of cross-contamination
- Suitable for long term storage of materials at a wide range of pH and temperatures
BENEFITS
Maintains sterility – Sterile filters are used to prevent contamination of the cell culture by microorganisms present in the air or culture media
Cell retention – This can be achieved using tangential flow filtration (TFF), which utilizes a semi-permeable membrane that allows the passage of small molecules but not cells
Product harvesting – Once the cells produce the product, it can be harvested from the culture broth using depth filters, which trap cells and other large particles, or by using chromatography techniques
High-quality effluent
Compact footprint
Efficient removal of contaminants
Independent control of sludge retention time and hydraulic retention time
Can be used for a wider range of applications
| S.No | Description |
|---|---|
| 1 | MPC coupling plug |
| 2 | MPC coupling body |
| 3 | TPE tube |
| 4 | Pinch clamp |
| 5 | Needle-free site |
| 6 | Slide clamp |
| 7 | DO sensor port |
| 8 | Female luer with cap |
| 9 | pH sensor port |
| 10 | Disc port connector |
| 11 | Check valvehose barb |
| 12 | Air inlet vent filter |
| 13 | Mesh filter |
| S.No | Description |
|---|---|
| Filter material | Nylon |
| Filter pore size | 1.2µm |
| Tube length | 5 cm to 200 cm |
| Tube diameter (ID x OD) | 6.4 x 9.5 mm (1/4 x 5/8 in.) |
| Disc port | 6.4 mm, 9.5 mm, 12.7 mm |
| Connector | 19.05 mm , 25.4 mm |
APPLICATIONS
Inoculation and Cell Culture: Inoculation of a culture medium with the desired cells, such as yeast, bacteria, or mammalian cells in the Bioreactor Filter Bag. Cells grow and multiply in the Bioreactor Filter Bag under controlled conditions.
Product Formation: When the cells grow and metabolize nutrients, they produce the desired product, which could be antibiotics, enzymes, proteins, or biofuels.
Recombinant Protein production: To produce insulin, growth factors, and hormones.
Harvesting: Once product reaches required concentration, the culture is harvested from the Bioreactor Filter Bag. Harvesting methods may involve centrifugation, filtration, or other separation techniques.
Downstream Processing: Purification, concentration, and formulation to produce the final product in a purified and stable form.
Vaccine production: Bioreactor Filter Bags are used to produce viral vaccines, recombinant subunit vaccines, and other types of vaccines for preventing infectious diseases.
Cell Expansion: Bioreactor Filter Bags are used to expand and grow therapeutic cells (stem cells/ immune cells). The controlled environment in the Bioreactor Filter Bag ensures optimal cell growth.
Ordering Information
| Part Number | Product Description | Volume | Working Volume | Outer Bag Size WxL (mm) | Inner Bag Size WxL (mm) |
|---|---|---|---|---|---|
| 2DBRFBAA-01 | Bioreactor Filter Bag 2 L | 2 L | 1 L | 292 x 575 | 272 x 415 |
| 2DBRFBAB-01 | Bioreactor Filter Bag 5 L | 5 L | 2.5 L | 365 x 565 | 345 x 405 |
| 2DBRFBAC-01 | Bioreactor Filter Bag 10 L | 10 L | 5 L | 365 x 565 | 345 x 445 |
| 2DBRFBAD-01 | Bioreactor Filter Bag 20 L | 20 L | 10 L | 625 x 710 | 605 x 586 |
| 2DBRFBAE-01 | Bioreactor Filter Bag 22 L | 22 L | 11 L | 500 x 870 | 480 x 750 |
| 2DBRFBAF-01 | Bioreactor Filter Bag 50 L | 50 L | 25 L | 760 x 870 | 740 x 750 |
