CytoRunTM
Bioreactor
CellBios® Bioreactor is a single use reactor bag used for cell separation, processing and expansion during cell culture and drug discovery applications. It is made up of multi layered PE film and Nylon filter material with a pore size of about 1.2µm. CellBios® Bioreactors provide a secure environment for cultivating cells, minimizing the risk of contamination that can disrupt the production. A bioreactor with a perfusion filter is a specialized bioreactor used in the biopharmaceutical industry for cultivating cells, fluid handling, purification, and producing various products.
CytoRunTM
Bioreactor
Offered in 7 different configurations from 1 L to 50 L. Further options are available through our custom order process through which we can accommodate most end users’ process needs.
CytoRunTM
Bioreactor with Perfusion filter
Offered in 6 different configurations from 2 L to 50 L. It is made up of multi layered PE film and Nylon filter material with varying pore sizes.
Features
- Specially designed for easy fluid handling
- Excellent durability and toughness
- Highly sealable and weldable to provide leak resistance
- Exhibits superior clarity and transparency for good visibility
- Excellent gas barrier properties
- Reduces the risk of cross-contamination
- Suitable for long term storage of materials at a wide range of pH and temperatures
- Superior filter for harvesting extracellular and intracellular products
Benefits
Gentle mixing: Bioreactors use a gentle rocking motion to mix the cell culture minimizing the shear stress on the cells. This is crucial as shear stress from impellers can damage the cells, reducing viability and ultimately impacting yield.
Simplified design: The lack of moving parts resulting in a smaller overall footprint and the potential use of simpler materials make them easier to build and maintain compared to traditional stirred-tank bioreactors.
Easier monitoring and analysis: Cells are spread out in a single layer, making them easier to observe under microscopes and for various analytical techniques.
Integrated filters: Bioreactors with integrated filters allow for continuous or fed-batch operation. This enables the removal of waste products and the addition of fresh nutrients to the culture medium without interrupting the process.
Improved harvest clarity: Pre-filtration of the cell culture broth using the integrated filter before cell lysis can help improve the harvest & clarity, simplifying downstream processing and improving the efficiency of purification steps.
Reduced Contamination Risk: Rocking single-use bioreactor bags with filters ensures a contaminant-free environment throughout the culturing process.
| S.No | Specification |
|---|---|
| 1 | MPC coupling plug |
| 2 | MPC coupling body |
| 3 | TPE tube |
| 4 | Pinch clamp |
| 5 | Needle-free site |
| 6 | Slide clamp |
| 7 | Female luer with cap |
| 8 | Air inlet vent filter |
| 9 | Disc port connector |
| 10 | Check valvehose barb |
| 11 | Air inlet vent filter |
| 12 | Do sensor port |
| 13 | pH sensor port |
| 14 | Mesh filter |
| S.No. | Description |
|---|---|
| Filter pore size | 1.2µm |
| Tube length | 5 cm to 200 cm |
| Tube diameter (ID x OD) | 6.4 x 9.5 mm (1/4 x 5/8 in.) |
| Disc port | 6.4 mm, 9.5 mm, 12.7 mm |
| Connector | 19.05 mm, 25.4 mm |
Applications
Monoclonal Antibodies (mAbs): CellBios® Bioreactor helps maintain a healthy environment for these complex molecules, leading to higher yields and improved quality for cancer and autoimmune disease treatments.
Recombinant Proteins: CellBios® Bioreactor can be used in therapeutic proteins like insulin and growth factors benefit from the controlled environment and waste product removal offered by perfusion, resulting in increased yields of functional proteins.
Stem Cell Culture: CellBios® Bioreactor offers a sterile and controlled environment for large-scale stem cell expansion for therapeutic applications.
Viral Vectors: Vectors are used in gene therapy applications. CellBios Bioreactor can help achieve high viral titers, which is essential for effective gene delivery.
Tissue Engineering: CellBios® Bioreactors can be used to create artificial tissues or organs by culturing specific cell types and providing a controlled environment for their growth and differentiation.
Vaccine production: CellBios® Bioreactor bags can be used to produce viral vaccines, recombinant subunit vaccines, and other types of vaccines for preventing infectious diseases.
Cell Therapy: CellBios® Bioreactor can be used in expanding large quantities of therapeutic cells like CAR-T cells, stem cells, and NK cells used in cell-based therapies.
Bioreactor
Ordering Information
| Part Number | Product Description | Volume | Working Volume | Outer Bag Size WxL | Inner Bag Size WxL |
|---|---|---|---|---|---|
| 2DBRBA-01 | Bioreactor Bag 1 L | 1 L | 500 mL | 292 x 575 (mm) | 272 x 265 (mm) |
| 2DBRBB-01 | Bioreactor Bag 2 L | 2 L | 1 L | 292 x 575 (mm) | 272 x 415 (mm) |
| 2DBRBC-01 | Bioreactor Bag 5 L | 5 L | 2.5 L | 365 x 565 (mm) | 345 x 405 (mm) |
| 2DBRBD-01 | Bioreactor Bag 10 L | 10 L | 5 L | 365 x 565 (mm) | 345 x 445 (mm) |
| 2DBRBE-01 | Bioreactor Bag 20 L | 20 L | 10 L | 625 x 710 (mm) | 605 x 586 (mm) |
| 2DBRBF-01 | Bioreactor Bag 22 L | 22 L | 11 L | 500 x 870 (mm) | 480 x 750 (mm) |
| 2DBRBG-01 | Bioreactor Bag 50 L | 50 L | 25 L | 760 x 870 (mm) | 740 x 750 (mm) |
Bioreactor with Perfusion filter
Ordering Information
| Part Number | Product Description | Volume | Working Volume | Outer Bag Size WxL (mm) | Inner Bag Size WxL (mm) |
|---|---|---|---|---|---|
| 2DBRFBA-01 | Bioreactor Filter Bag 2 L | 2 L | 1 L | 292 x 575 | 272 x 415 |
| 2DBRFBB-01 | Bioreactor Filter Bag 5 L | 5 L | 2.5 L | 365 x 565 | 345 x 405 |
| 2DBRFBC-01 | Bioreactor Filter Bag 10 L | 10 L | 5 L | 365 x 565 | 345 x 445 |
| 2DBRFBD-01 | Bioreactor Filter Bag 20 L | 20 L | 10 L | 625 x 710 | 605 x 586 |
| 2DBRFBE-01 | Bioreactor Filter Bag 22 L | 22 L | 11 L | 500 x 870 | 480 x 750 |
| 2DBRFBF-01 | Bioreactor Filter Bag 50 L | 50 L | 25 L | 760 x 870 | 740 x 750 |
